The yeast checkpoint kinase Dun1 downregulates DIN7 in the absence of DNA damage

Abstract

Yeast DIN7 is a DNA damage-inducible gene. Its expression is increased in the absence of Dun1, a DNA damage checkpoint kinase. We identified a DIN7 promoter region responsible for Dun1-mediated down-regulation and found that DIN7 expression was not further increased in response to hydroxyurea in Δdun1 cells. Thus DIN7 repression by Dun1 can be released upon DNA damage.