Pengaruh Ekstrak Etanol Daun Inggu (Ruta angustifolia) terhadap Tebal Otot Polos Tuba Fallopi Tikus Strain Wistar Betina

Abstract

The highest drop out of hormonal contraceptive users caused by side effects is the background for research on the use of herbal plants as antifertility substitutes for hormonal contraceptive which have minimal effects. Inggu leaves (Ruta angsutifolia) contain compounds that are interfering hormonal work such as saponins, tannins, chalepins and chalepensins, so it can be antifertitlity. To determine ethanol extract of inggu leaves effect on reducing the thickness of the smooth muscle of fallopian tube in female rats. The study used randomized post-test only controlled group was conducted using experimental animals (Wistar strain rats) divided into 4 groups with different doses (0; 0.4; 0.8; and 1.2 g/kg BW ) in February until April 2022. Measurement of the fallopian tube smooth muscle layer thickness using an Olympus CX23 microscope and ImageJ application.: Rat fallopian tube smooth muscle thickness was reduced along the dose of inggu leaf ethanol extract increased that statistically significant (p = 0.046). Ethanol extract of inggu leaves can reduce the fallopian tube smooth muscle thickness with an optimal dose of 1.2 g/kg BW.