Efek Antiinflamasi dari Ekstrak Kulit Buah Durian (Durio zibethinus murray) terhadap Tikus Putih Jantan

Abstract

The observation on anti-inflammatory effects ofextract of durian rind(Durio zibethinus Murray) has been done. Extractof durian rind(Durio zibethinus Murray) dose were: 100 mg/kg, 200 mg/kg and 400 mg/kg. Tween 80 2% was used as negative control and diclofenac sodium 0.9 mg/200g was used as positive control. The parameter was the percentage of inflammation observed in the left foot of male albino rats induced by 1% suspension of carrageen. Measurements of parameter was done every 30 minutes for 360 minutes. The results showed that percentage of anti-inflammatory of diclofenac sodium 0.9 mg/200g, the extract in dose of 400 mg/kg, 200 mg/kg and 100 mg/kg were 64.9%, 61.86%, 52.98% and 48.58%respectively. It can be concluded that ethanolic extract of durian rind(Durio zibethinus Murray) has an anti-inflammatory effects. The optimal dose as an anti-inflammatory agentwas 400mg/kg BW