Study the topical effect of six days use of different lycopene doses on imiquimod-induce psoriasis-like skin inflammation in Mice

Abstract

Lycopene is a hydrocarbon phytochemical that is present in red vegetables and fruits, several studies reviewed the pharmacological properties of Lycopene across years ago and in different aspects including inflammation, cardiovascular disease, prostatic cancer and different dermatological complaints. Objective: we investigated the potential impact of two different doses of topical Lycopene and as add on therapy to Clobetasol on Psoriasis model that induced by Imiquimod in mice. Methods: This was accomplished by dividing 48 mice into six groups (8 mice per each group). All groups received Imiquimod for induction of Psoriasis (except Group I which is healthy group) across the experiment days. Group II (Induction group) received Petrolatum gel (Vaseline) for six days after 6 days induction period with Imiquimod. The rest groups III, IV,V,VI received Clobetasol propionate 0.05%, 0.125 mg/ml Lycopene, 0.25 mg/ml Lycopene and combination of 0.25 mg/ml Lycopene and 0.05% Clobetasol propionate ointments respectively once daily for six days after 6 days of induction period with Imiquimod.