A novel agarofuran sesquiterpene, celahin D from Celastrus hindsii BENTH

Abstract

A novel agarofuran sesquiterpene polyol ester, 1β,2β,6α15β-tetracetoxy-8β,9α-dibenzoyloxy-β- dihydroagarofuran (celahin D) (1), two known analogues of 1,1β- acetoxy-8β,9α-dibenzoyloxy-4α,6α-dihydroxy-2β(α- methylbutanoyloxy)-β-dihydroagarofuran (2) and 1β-acetoxy- 8β,9α-dibenzoyloxy-6α-hydroxy-2β(α-methylbutanoyloxy)-β- dihydroagarofuran (3), and a known cytotoxic sesquiterpene pyridine alkaloid, emarginatine E (4) were isolated from the stems of Celastrus hindsii BENTH. Three known triterpenes, loranthol (5), lupenone (6) and friedelinol (7) were also obtained from the titled plant. Structural elucidation of compound 1 was established by 2D NMR spectra.