Identification of protein c deficiency and antiphospholipid syndrome in the pregnant women is associated with immunological detection of cytomegalovirus and Toxoplasma Gondii infections

Abstract

This study was performed to clinically identify the most frequent causative agents of abortion and whether these etiological factors are associated or not. A total of 245 blood samples were collected from women, previously had an abortion. These samples were divided into three age groups: 18-23, 24-29 and 30-35 years old. The serum of each blood sample was separated and the anti-serum antibodies which were used including; Cytomegalo virus (CMV), Toxoplasma gondii, Rubella, protein C and antiphospholipid. Our data illustrated that CMV as the most predominant abortion agents (23.2%) while Rubella was the lowest, reported in (0.8%) of total serum samples. In this study, the association of protein C deficiency and antiphospholipid levels with the infectious agents (CMV, T. gondii and Rubella) were evaluated. We noticed that an elevation of protein C values was reported in the cases which were positive for CMV (P value ≤ 0.008). Similarly, an increasing of antiphospholipid values in the cases were positive for T. gondii (P value ≤ 0.01). While, no significant difference was observed between Rubella infection and both of protein C and antiphospholipid values. The authors concluded that the detection of the abortion infectious agents, CMV and T. gondii is a useful tool for early identification and treatment of protein C deficiency and antiphospholipid syndrome, respectively to avoid high venous thrombotic risks and the repeated abortion.