Metabolites of the endophytic fungus Penicillium sp. FJ-1 of Acanthus ilicifolius

Abstract

Two new compounds, named as (2R,3S )-pinobanksin-3-cinnamate (1), and 15α-hydroxy-(22E,24R)-ergosta-3,5,8(14),22-tetraen-7-one (2), were isolated from the endophytic fungus Penicillium sp. FJ-1 of Acanthus ilicifolius Linn. Their structures were elucidated on the basis of spectroscopic analysis. Additionally, compound 1 exhibited potent neuroprotective effects on corticosterone-damaged PC12 cells, and compound 2 showed potent cytotoxicity on glioma cell lines.