High stroke volume variation method by mannitol administration can decrease blood loss during donor hepatectomy

Abstract

Optimal fluid management to reduce blood loss during donor hepatectomy is important for maximizing donor safety. Mannitol can induce osmotic diuresis, helping prevent increased intravascular volume status. We therefore evaluated the effect of high stroke volume variation (SVV) method by mannitol administration and fluid restriction on blood loss during donor hepatectomy. In this prospective study, 64 donors scheduled for donor right hepatectomy were included and allocated into 2 groups. In group A, the SVV value of each patient was maintained at 10% to 20% during hepatic resection with 0.5 g/kg mannitol administration and fluid restriction at a rate of 2 to 4mL/kg/h. In group B, the SVV value was maintained at <10% by fluid administration at a rate of 6 to 10mL/kg/h without diuretic administration during surgery. Intraoperative blood loss was estimated by the loss of red cell mass. Surgeon satisfaction scores and postoperative outcomes, including acute kidney injury, abnormal chest radiographic findings, and hospital stay duration, were also assessed. SVV during hepatectomy was significantly higher in group A than in group B (11.0± 1.7 vs 6.5 ± 1.1, P< 0.001). The red cell mass loss was significantly lower in group A than in group B (145.4 ±107.6 vs 307.9 ± 110.7mL, P< 0.001). Surgeon satisfaction scores were higher in group A than in group B (2.8 ±0.5 vs 2.0 ±0.6, P< 0.001). The incidence of acute kidney injury, abnormal chest radiographic findings, and duration of hospital stay did not significantly differ between the 2 groups. Maintenance of high SVV by mannitol administration is effective and safe for reducing blood loss during donor hepatectomy.