ERG protein expression in human tumors detected with a rabbit monoclonal antibody

40Citations
Citations of this article
21Readers
Mendeley users who have this article in their library.

Abstract

Avian v-ets erythroblastosis virus E26 oncogene homolog (ERG) is highly sensitive and specific for endothelial neoplasms and specific for prostate carcinoma. We characterized a rabbit anti-ERG antibody as an immunohistochemical agent to detect ERG expression in various tumors using tissue microarrays with a wide array of epithelial and mesenchymal tumors. ERG was positive in 63 (38%) of 168 prostate carcinomas and negative in all other epithelial tumors. ERG was positive in all 125 vascular lesions. It was also positive in the sarcomatoid component of a high-grade urothelial carcinoma and 6 (40%) of 15 meningiomas. Twelve (80%) of 15 meningiomas were positive for Fli1, including all 6 ERG-positive cases. Positive immunostaining with this antibody is therefore highly specific for prostate carcinoma and vascular lesions, with a few caveats. ERG is rarely detected in nonvascular mesenchymal tumors with this antibody. Furthermore, about 40% of meningiomas are also positive for ERG immunohistochemically, probably because of cross-reactivity with Fli1. © American Society for Clinical Pathology.

Cite

CITATION STYLE

APA

Yaskiv, O., Rubin, B. P., He, H., Falzarano, S., Magi-Galluzzi, C., & Zhou, M. (2012). ERG protein expression in human tumors detected with a rabbit monoclonal antibody. American Journal of Clinical Pathology, 138(6), 803–810. https://doi.org/10.1309/AJCP3K5VUFALZTKC

Register to see more suggestions

Mendeley helps you to discover research relevant for your work.

Already have an account?

Save time finding and organizing research with Mendeley

Sign up for free