Asymmetric Rh-catalyzed intermolecular hydroacylation of 1,5-hexadiene with salicylaldehyde

Abstract

Asymmetric intermolecular hydroacylation between salicylaldehyde (1) and 1,5-hexadiene (2) using a combination of [RhCl(C8H14) 2]2 (0.10 eq), (S)-BINAP (0.10 eq), and ZnBr2 (0.20 eq) afforded an enantiomerically enriched hydroacylated product iso-3 of 84% ee, along with an achiral product normal-3. © 2009 Pharmaceutical Society of Japan.