It has already been shown that tetanus toxoid (TTd) hyper-immunization is a suitable experimental method for creating the animal model of antiphospholipid syndrome (APS) in BALB/c mice. The severity of APS pathology in BALB/c mice mainly correlates to the affinity of anti-β 2 glycoprotein I (β 2GPI) antibodies. In this study we have investigated reproductive pathology induced in C57BL/6 mice by TTd hyper-immunization using a combination of different pretreatments (complete Freund's adjuvant or glycerol) and adjuvants (alhydrogel or glycerol). A decrease in fecundity was recorded in only C57BL/6 mice immunized with alhydrogel adjuvant, irrespective of the kind of applied pretreatment; it was associated with an increase in abundance of low affinity anti-β 2GPI IgG antibodies and Th1 prevalence. © The Author(s) 2011.
CITATION STYLE
Živković, I., Petrušić, V., Stojanović, M., Inić-Kanada, A., Stojićević, I., & Dimitrijević, L. (2012). Induction of decreased fecundity by tetanus toxoid hyper-immunization in C57BL/6 mice depends on the applied adjuvant. Innate Immunity, 18(2), 333–342. https://doi.org/10.1177/1753425911407361
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