Bacillomycin Lc, a New Antibiotic of the Iturin Group: Isolations, Structures, and Antifungal Activities of the Congeners

Abstract

Bacillomycin Lc, a new antifungal antibiotic of the iturin class, was isolated from a strain of Bacillus subtilis as a set of five congeners. The structure as determined by chemical and spectrometric analyses has been shown to differ from that of bacillomycin L by sequence changes from aspartate-1 to asparagine-1 and from glutamine-5 to glutamate-5. The five congeners differ from each other only in the structure of the aliphatic side chain of the constituent β-amino acid. The hydrophobicity of the β-amino acid affects the antifungal activity of the congener, as activity increased in the order of increased congener retention on a reversed-phase HPLC column. © 1995, JAPAN ANTIBIOTICS RESEARCH ASSOCIATION. All rights reserved.