SARS-CoV-2 envelope protein topology in eukaryotic membranes: SARS-CoV-2 E protein topology

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Abstract

Coronavirus E protein is a small membrane protein found in the virus envelope. Different coronavirus E proteins share striking biochemical and functional similarities, but sequence conservation is limited. In this report, we studied the E protein topology from the new SARS-CoV-2 virus both in microsomal membranes and in mammalian cells. Experimental data reveal that E protein is a single-spanning membrane protein with the N-terminus being translocated across the membrane, while the C-terminus is exposed to the cytoplasmic side (Nt lum /Ct cyt). The defined membrane protein topology of SARS-CoV-2 E protein may provide a useful framework to understand its interaction with other viral and host components and contribute to establish the basis to tackle the pathogenesis of SARS-CoV-2.

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Duart, G., García-Murria, M. J., Grau, B., Acosta-Cáceres, J. M., Martínez-Gil, L., & Mingarro, I. (2020). SARS-CoV-2 envelope protein topology in eukaryotic membranes: SARS-CoV-2 E protein topology. Open Biology, 10(9). https://doi.org/10.1098/rsob.200209

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