Control of neural synchrony with light activated opsins

Abstract

Problems with electrical stimulation include the lack of mechanistic understanding of the effect of the electrical stimulation on brain dynamics, trial and error methodology to determine effective stimulation parameters, limited battery life resulting in repeated invasive surgeries, and difficulty in producing purely inhibitory stimulus. Recent developments in the field of molecular and genetic biology now offer the opportunity to use optical techniques to modulate neuronal activity in vivo by making neurons light sensitive through the use of light activated opsins. Copy to clipboard Provided by the Springer Nature SharedIt content-sharing initiative Keywords * Electrical Stimulation * Feedback Signal * Synchronous State * Network Synchrony * Neuron Oscillator Volume 11 Supplement 1 Nineteenth Annual Computational Neuroscience Meeting: CNS*2010 [RAW_REF_TEXT] Poster Presentation [/RAW_REF_TEXT] [RAW_REF_TEXT] Open Access [/RAW_REF_TEXT] [RAW_REF_TEXT] Published:20 July 2010 [/RAW_REF_TEXT] Control of neural synchrony with light activated opsins [RAW_REF_TEXT] Sachin S Talathi 1, [/RAW_REF_TEXT] [RAW_REF_TEXT] Shivakeshavan Ratnadurai2, [/RAW_REF_TEXT] [RAW_REF_TEXT] Svetlana Kantorovich4, [/RAW_REF_TEXT] [RAW_REF_TEXT] Paul R Carney1,3 & [/RAW_REF_TEXT] [RAW_REF_TEXT] Pramod P Khargonekar2 [/RAW_REF_TEXT] BMC Neuroscience volume 11, Article number: Problems with electrical stimulation include the lack of mechanistic understanding of the effect of the electrical stimulation on brain dynamics, trial and error methodology to determine effective stimulation parameters, limited battery life resulting in repeated invasive surgeries, and difficulty in producing purely inhibitory stimulus. Recent developments in the field of molecular and genetic biology now offer the opportunity to use optical techniques to modulate neuronal activity in vivo by making neurons light sensitive through the use of light activated opsins.