Synthesis and antimicrobial activity of novel Indol compounds containing 2-azitidinones and 1,3,4 Oxadiazoles

Abstract

New novel derivatives of 4-(3-(1-((4-acetyl-5-methyl-5-(p-substituted phenyl)-4,5-dihydro- 1,3,4-oxadiazol-2-yl)methyl)-5-chloro-1H-indol-3-yl)-1-(pyridin-4-yl)-1H-pyrazol-4-yl)-3-chloro-1- (4 substituted phenyl)azetidin-2-one (5a-g) were prepared by the condensation of acetohydrazide (4a-g) with acetic anhydride. The compound 4(a-g) was obtained by the reaction of (3) with 4- substituted acetophenone in the presence of glacial aceticacid. The synthon (3) was obtained by the reaction of compound(2) with hydrazine hydrate in ethanol. The compound (2) was obtained by the reaction of (1H-indol-1-yl)acetate(1) with monochloroacetyl chloride in the presence of triethylamine in dioxane. The structure of the newly synthesized compounds were charecterized by IR, NMR, Mass and elemental analysis.