Effect of garlic extract (Allium sativum) on hepatic microanatomy structure and serum glutamate-pyruvate transaminase levels in rats after oral treatment of CCl4

Abstract

Garlic (Allium sativum L.) is known to have various pharmacological activities, such as antidiabetic, antihypertensive, anti-cholesterol, anti-atherosclerosis, thrombocyte antiaggregation, initiate fibrinolysis, antiviral and antimicrobial, anticancer and antioxidant. The objectives of this research were to determine the effect of garlic extract (Allium sativum L.) on the microanatomy structure of liver and the serum glutamate-pyruvate transaminase (SGPT) levels in rats (Rattus norvegicus L.) after the oral treatment of carbon tetrachloride (CCl4). The study was conducted by using 25 Wistar strain rat aged 2-3 months with body weight 200-250 grams divided into five groups, each group consisted of 5 rats as replicates which kept under the same conditions and treated for 28 days. The results showed that the treatment of garlic extract had an effect on the improvement of microanatomy structure of damaged liver cells in rats after oral treatment of carbon tetrachloride (CCl4). The damage was in the form of fatty liver, pyknotic, karyorrhexis, karyolysis and central vein dilatation. The treatment of garlic extract also reduced the serum pyruvate-transaminase glutamate (SGPT) levels in rats after the oral treatment of carbon tetrachloride (CCl4).