Ultrasensitive electrochemical detection of cancer cell using modified graphene nanostructures

Abstract

In this paper the ultra sensitive electrochemical cytosensor was introduced for prostate cancer cells (Du-145) detection. In this cytosensor Du-145 cells were captured on modified gold electrode by using CD-166 antibody. Also reduced graphene oxide/ gold nanoparticle/ CD-166- horseradish peroxidase (rGO/ AuNP/Ab-HRP) nanoprobes as efficient signal amplifiers was designed for the cancer cells recognition.The presented cytosensor exhibited a good cell-capture ability, wide detection range and low detection limit of 50 cells.This cytosensor has great potential for cancer cell detection in clinical and pathological application.