SIRT6 enhances oxidative phosphorylation in breast cancer and promotes mammary tumorigenesis in mice

Abstract

Background: Sirtuin 6 (SIRT6) is a NAD +-dependent deacetylase with key roles in cell metabolism. High SIRT6 expression is associated with adverse prognosis in breast cancer (BC) patients. However, the mechanisms through which SIRT6 exerts its pro-oncogenic effects in BC remain unclear. Here, we sought to define the role of SIRT6 in BC cell metabolism and in mouse polyoma middle T antigen (PyMT)-driven mammary tumors.