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Background: Sirtuin 6 (SIRT6) is a NAD +-dependent deacetylase with key roles in cell metabolism. High SIRT6 expression is associated with adverse prognosis in breast cancer (BC) patients. However, the mechanisms through which SIRT6 exerts its pro-oncogenic effects in BC remain unclear. Here, we sought to define the role of SIRT6 in BC cell metabolism and in mouse polyoma middle T antigen (PyMT)-driven mammary tumors.
Becherini, P., Caffa, I., Piacente, F., Damonte, P., Vellone, V. G., Passalacqua, M., … Nencioni, A. (2021). SIRT6 enhances oxidative phosphorylation in breast cancer and promotes mammary tumorigenesis in mice. Cancer & Metabolism, 9(1). https://doi.org/10.1186/s40170-021-00240-1