Validity and Reliability of the 32-Item Motor Function Measure in 2- to 5-Year-Olds with Neuromuscular Disorders and 2- to 25-Year-Olds with Spinal Muscular Atrophy

Abstract

Introduction: To investigate the validity and reliability of the 32-item Motor Function Measure (MFM32) in individuals with neuromuscular disorders (NMD), including spinal muscular atrophy (SMA), aged 2–5 years, and in non-ambulant individuals with Types 2 or 3 SMA, aged 2–25 years. Methods: Test–retest reliability (intraclass correlation coefficient [ICC]), internal consistency (Cronbach’s alpha [α]), convergent validity (Spearman rank-order correlations), and known-groups validity (analysis of covariance comparing groups defined by the Clinical Global Impression of Severity [CGI-S] scale and Vignos grade) were calculated. The analysis was performed on a dataset provided by Hospices Civils De Lyon, extracted from the multinational MFM32 database. A total of 165 individuals were included in the analyses, of whom 84 were in the NMD group (aged 2–5 years) and 81 were in the SMA group (aged 2–25 years). Results: Strong evidence of test–retest reliability (ICC: 2- to 5-years’ population = 0.94–0.95; 2- to 25-years’ population = 0.97), internal consistency (Cronbach’s α: 2- to 5-years’ population = 0.96; 2- to 25-years’ population = 0.95), convergent validity (2- to 5-years’ population: CGI-S rho = − 0.84, Vignos grade rho = − 0.79; 2- to 25-years’ population: CGI-S rho = − 0.49), and known-groups validity (all P < 0.001) were demonstrated. Conclusions: These analyses provide supportive evidence of the validity and reliability of the MFM32 in younger individuals with NMDs, aged 2–5 years, and in non-ambulant individuals with Types 2 or 3 SMA, aged 2–25 years, supporting the use of the MFM32 across a wide age range.