Identification and characterization of the gyrB gene from Treponema pallidum subsp. pallidum

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Abstract

The nucleotide sequence of a DNA gyrase B subunit gene (gyrB) from Treponema pallidum has been determined. Southern blot analysis of T. pallidum chromosomal DNA indicated that this gene is present as a single copy. The organization of genes flanking the gyrB gene is unique in comparison to that of other bacteria. The gyrB gene encodes a 637 amino acid protein whose deduced sequence has a high degree of homology with type-II topoisomerase ATPase subunits (GyrB and ParE). Five type-II topoisomerase motifs, an ATP- binding site (Walker A), and amino acid residues that putatively interact with ATP, are highly conserved in the T. pallidum GyrB protein.

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Stamm, L. V., Greene, S. R., & Barnes, N. Y. (1997). Identification and characterization of the gyrB gene from Treponema pallidum subsp. pallidum. FEMS Microbiology Letters, 153(1), 129–134. https://doi.org/10.1016/S0378-1097(97)00247-4

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