In this issue of Cell Stem Cell, Pei et al. (2018) demonstrate that leukemic stem cells (LSCs) have enhanced mitochondrial fission, which is positively regulated by FIS1. FIS1 is necessary to maintain LSC function; thus, targeting its expression and mitochondrial fission is a novel approach to decrease stemness and increase differentiation in Acute Myeloid Leukemia.
Schimmer, A. D. (2018, July 5). Mitochondrial Shapeshifting Impacts AML Stemness and Differentiation. Cell Stem Cell. Cell Press. https://doi.org/10.1016/j.stem.2018.05.026