Prolonged adjuvant chemotherapy in breast cancer: The scandinavian adjuvant chemotherapy study 2

Abstract

Eleven hundred and sixteen primary female breast cancer patients received one short perioperative chemotherapy course. the node negative patients were randomised between immuno-therapy (corynebacterium parvum s.c. around the scar 2 weeks after mastectomy). or no further adjuvant therapy. A moderate, but significant delaying effect was observed, without side effects. the node positive patients were randomised to four groups: I) the same immunotherapy as in the node negative patients. 2) CMF for 1 year, 3) combination of these two treatments, or 4) no further adjuvant therapy. the prolonged chemotherapy had a significant positive effect, but also considerable and distressing side effects. the immunotherapy had a non-significant negative effect in the node positive patients, but without side effects. ©1989 Informa UK Ltd All rights reserved: reproduction in whole or part not permitted.