Parkinson's disease-associated PINK1 and Parkin maintain mitochondrial health through promoting mitophagy, the autophagic removal of damaged mitochondria, in non-neuronal cells. Whether they do so in neurons has been controversial. A new study aims to resolve the controversy.
Lu, B. (2014, October 20). Neuronal mitophagy: Long-distance delivery or eating locally? Current Biology. Cell Press. https://doi.org/10.1016/j.cub.2014.09.037