Several recent papers show that differences in histone modification and the use of histone variants at the 5′ and 3′ ends of genes influence the location and kinetics of transcriptional initiation. The ultimate target of most epigenetic mechanisms may be the regulation of nucleosome occupancy, which in turn controls access to DNA at specific genomic locations. ©2005 Elsevier Inc.
Lieb, J. D., & Clarke, N. D. (2005, December 29). Control of transcription through intragenic patterns of nucleosome composition. Cell. https://doi.org/10.1016/j.cell.2005.12.010