Pedunculopontine arousal system physiology - Implications for insomnia

13Citations
Citations of this article
31Readers
Mendeley users who have this article in their library.

Abstract

We consider insomnia a disorder of waking rather than a disorder of sleep. This review examines the role of the reticular activating system, especially the pedunculopontine nucleus, in the symptoms of insomnia, mainly representing an overactive waking drive. We determined that high frequency activity during waking and REM sleep is controlled by two different intracellular pathways and channel types in PPN cells. We found three different PPN cell types that have one or both channels and may be active during waking only, REM sleep only, or both. These discoveries point to a specific mechanism and novel therapeutic avenues for insomnia.

Cite

CITATION STYLE

APA

Garcia-Rilla, E., Lustera, B., Mahaffeya, S., Bisagnoh, V., & Urhanob, F. J. (2015, April 1). Pedunculopontine arousal system physiology - Implications for insomnia. Sleep Science. FLASS. https://doi.org/10.1016/j.slsci.2015.06.002

Register to see more suggestions

Mendeley helps you to discover research relevant for your work.

Already have an account?

Save time finding and organizing research with Mendeley

Sign up for free