Wound Healing Management Bioinformatics Approach

Abstract

The proposed review aim is an attempt to consider the wound healing process as a bioinformatics multivariate mathematical-biological- medical problem and attract attention to creation of unified approach to wound healing management, particularly for optimization of medical treatment. Wound healing process is closely associated with scarring problem which has economical, psychological and therapeutic consequences. Vast investigation in medicine, pharmacology and biology leads to creation of very complex mathematical models and to accumulation of huge medical data array, which require correct interpretation. Nanotechnology and nanomaterials for medical and pharmaceutical purposes give people a lot of possibilities to find new peculiarities and rules how to improve/accelerate/modify some biological processes. The cellular and molecular mechanisms underpinning tissue repair and its failure to heal are still poorly understood, and current therapies are limited. Poor wound healing after trauma, surgery, acute illness, or chronic disease conditions affects millions of people worldwide each year and is the consequence of poorly regulated elements of the healthy tissue repair response, including inflammation, angiogenesis, matrix deposition, and cell recruitment. Failure of one or several of these cellular processes is generally linked to an underlying clinical condition, such as vascular disease, diabetes, or aging, which are all frequently associated with healing pathologies. The search for clinical strategies that might improve the body’s natural repair mechanisms will need to be based on a thorough understanding of the basic biology of repair and regeneration.