Anti-tumor activity of N4 [(E)-1-(2-hydroxyphenyl) methylidene], N4 -[(E)-2-phenylethylidene], N4 [(E,2E)-3-phenyl-2- propenylidene], and N4 [(E)ethylidene] Isonicotinohydrazide on K562 and Jurkat cell lines

Abstract

Using the water eliminated mechanism, reactions of 4-pyridinecarboxylic acid hydrazide and salicylaldehyde, benzaldehyde, cinnamaldehyde, and formaldehyde afforded the corresponding N4 [(E)-1-(2-hydroxyphenyl) methylidene] (NHPM), N4 -[(E)-2-phenylethylidene] (NPI), N 4 [(E,2E)-3-phenyl-2-propenylidene] (NPPI), and N4 [(E) ethylidene] (NEI) isonicotinohydrazide, in high yields, after several minutes, as reported. These new compounds have shown antitumor activity against two kinds of cancer cells, which are K562 (human chronic myeloid leukemia) and Jurkat (human T lymphocyte carcinoma).