Sperm DNA integrity from sperm to egg

Abstract

This article has established that sperm DNA integrity is both extremely fragile and exceedingly important for male fertility. The 2 types of DNA appear to be distinct and independently packaged molecules; however, research has demonstrated the symbiotic nature of these structures in contributing to male infertility. Data must continue to be gathered to establish strong correlations between traditional semen analysis parameters and sperm DNA integrity; this information remains controversial and useless in clinical practice until new techniques for the diagnosis and treatment of sperm DNA can be established. More modern technology must be employed to correlate such information into useful clinical knowledge. Copyright © American Society of Andrology.