Delayed gadolinium-enhanced MRI of cartilage (dGEMRIC) in early knee osteoarthritis

Abstract

Delayed contrast-enhanced MRI of cartilage (dGEMRIC) is a noninvasive technique to study cartilage glycosaminoglycan (GAG) content in vivo. This study evaluates dGEMRIC in patients with preradiographic degenerative cartilage changes. Seventeen knees in 15 patients (age 35-70) with arthroscopically verified cartilage changes (softening and fibrillations) in the medial or lateral femoral compartment, knee pain, and normal weight-bearing radiography were included. MRI (1.5 T) was performed precontrast and at 1.5 and 3 hr after an intravenous injection of Gd-DTPA2- at 0.3 mmol/kg body weight. T1 measurements were made in regions of interest in medial and lateral femoral cartilage using sets of five turbo inversion recovery images. Precontrast, R1 (R1 = 1/T1, 1/s) was slightly lower in diseased compared to reference compartment, indicating increased hydration (P = 0.01). Postcontrast, R1 was higher in diseased than in reference compartment at 1.5 hr, 3.45 ± 0.90 and 2.64 ± 0.58 (mean ± SD), respectively (P < 0.01), as well as at 3 hr, 2.94 ± 0.60 and 2.50 ± 0.37, respectively (P = 0.01). The washout of the contrast medium was faster in diseased cartilage as shown by a higher R1 at 1.5 than at 3 hr in the diseased but not in the reference compartment. In conclusion, dGEMRIC can identify GAG loss in early stage cartilage disease with a higher sensitivity at 1.5 than 3 hr. © 2003 Wiley-Liss, Inc.