Leptospirosis in Mexico: Epidemiology and potential distribution of human cases

Abstract

Background: Leptospirosis is widespread in Mexico, yet the potential distribution and risk of the disease remain unknown. Methodology/Principal Findings: We analysed morbidity and mortality according to age and gender based on three sources of data reported by theMinistry of Health and the National Institute of Geography and Statics of Mexico, for the decade 2000-2010. A total of 1,547 cases were reported in 27 states, the majority of which were registered during the rainy season, and the most affected age group was 25-44 years old. Although leptospirosis has been reported as an occupational disease of males, analysis of morbidity inMexico showed nomale preference. A total number of 198 deaths were registered in 21 states,mainly in urban settings. Mortality was higher inmales (61.1%) as compared to females (38.9%), and the case fatality ratio was also increased in males. The overall case fatality ratio inMexico was elevated (12.8%), as compared to other countries.We additionally determined the potential disease distribution by examining the spatial epidemiology combined with spatialmodeling using ecological nichemodeling techniques. We identified regions where leptospirosis could be present and created a potential distribution map using bioclimatic variables derived fromtemperature and precipitation. Our data show that the distribution of the cases was more related to temperature (75%) than to precipitation variables. Ecological niche modeling showed predictive areas that were widely distributed in central and southern Mexico, excluding areas characterized by extreme climates. Conclusions/Significance: In conclusion, an epidemiological surveillance of leptospirosis is recommended in Mexico, since 55.7%of the country has environmental conditions fulfilling the criteria that favor the presence of the disease. Copyright: