Organocatalytic asymmetric addition of naphthols and electron-rich phenols to isatin-derived ketimines: Highly enantioselective construction of tetrasubstituted stereocenters

112Citations
Citations of this article
42Readers
Mendeley users who have this article in their library.
Get full text

Abstract

A quinine-derived thiourea organocatalyst promoted the highly enantioselective addition of naphthols and activated phenols to ketimines derived from isatins. The reaction afforded chiral 3-amino-2-oxindoles with a quaternary stereocenter in high yields (up to 99%) with excellent enantioselectivity (up to 99%ee). To the best of our knowledge, this transformation is the first highly enantioselective addition of naphthols to ketimines.

Cite

CITATION STYLE

APA

Montesinos-Magraner, M., Vila, C., Cantõn, R., Blay, G., Fernández, I., Muñoz, M. C., & Pedro, J. R. (2015). Organocatalytic asymmetric addition of naphthols and electron-rich phenols to isatin-derived ketimines: Highly enantioselective construction of tetrasubstituted stereocenters. Angewandte Chemie - International Edition, 54(21), 6320–6324. https://doi.org/10.1002/anie.201501273

Register to see more suggestions

Mendeley helps you to discover research relevant for your work.

Already have an account?

Save time finding and organizing research with Mendeley

Sign up for free