The molecular physiology of sodium-and proton-coupled solute transporters

Abstract

The expression of cloned Na+- and H+-coupled solute transporters in Xenopus laevis oocytes has permitted detailed molecular and biophysical analysis and illuminated unique mechanistic features. The identification of missense mutations in inherited diseases and site-directed mutagenesis studies have enhanced our understanding of their roles in physiological and pathological processes. © 1998 Int. Union Physiol. Sci./Am.Physiol. Soc.