Effect of an siRNA Therapeutic Targeting PCSK9 on Atherogenic Lipoproteins

  • Ray K
  • Stoekenbroek R
  • Kallend D
  • et al.
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Abstract

Background: The ORION-1 trial (Trial to Evaluate the Effect of ALN-PCSSC Treatment on Low Density Lipoprotein Cholesterol [LDL-C]) demonstrated that inclisiran, an siRNA therapeutic that targets pr...

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Ray, K. K., Stoekenbroek, R. M., Kallend, D., Leiter, L. A., Landmesser, U., Wright, R. S., … Kastelein, J. J. P. (2018). Effect of an siRNA Therapeutic Targeting PCSK9 on Atherogenic Lipoproteins. Circulation, 138(13), 1304–1316. https://doi.org/10.1161/circulationaha.118.034710

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