Circulating concentrations of immunoreactive peptide 7B2 in certain pathophysiological conditions, and response to oral glucose load

Abstract

A peptide, 7B2, originally isolated from pituitary, is present in endocrine tumors, with high concentrations in pancreatic islet tumors. Plasma from most of these patients showed very high immunoreactivity to 7B2 (IR-7B2). To assess whether or not there is any alteration in circulating 7B2 concentrations due to age, sex, etc., we measured concentrations in plasma in 96 fasting healthy subjects, ages three months to 91 years; in patients with various other conditions, including pregnancy; and in cord blood. The response of circulating IR-7B2 to oral glucose was also evaluated. We found particularly high IR-7B2 concentrations in cord blood. Postnatally the concentrations were lower and decreased gradually with age to values for adults [15.6 (SE 2.9) pmol/L], increasing again significantly (P < 0.01) in persons older than 70 years [37.1 (SE 32) pmol/L]. There was no significant sex-related difference in values for plasma. For the pathological conditions studied, we observed significantly supranormal values in patients with chronic renal failure [175.1 (SE 35.9) pmol/L]. Some of the pregnant patients in their third trimester also showed high values. A small but significant increase in plasma IR-7B2 was observed after a glucose load, both in control subjects and diabetics. Perhaps the kidney plays a major role in 7B2 degradation.