Excision of sclerocorneal limbus in dogs and resulting clinical events: study of an experimental model

Abstract

The consequences of complete removal of the sclerocorneal limbus epithelium were evaluated, as well as the model for such, in which n-heptanol and superficial keratectomy were used. The association of n-heptanol and keratectomy allowed a complete excision of stem cells. Moreover, the destruction of these cells led to significant tectonic alterations that could be employed as a feasible model for clinical experimentation of corneal transplantation.As conseqüências da completa remoção do epitélio do limbo esclerocorneano foram avaliadas, bem como o modelo utilizado para tal, em que se empregou o n-heptanol e a ceratectomia superficial. O n-heptanol e a ceratectomia associados possibilitaram a completa excisão das células-tronco. Da destruição dessas células decorrem alterações tectônicas significativas factíveis para estudos dos transplantes de córnea.