Severe cryoglobulinemia in a patient with asymptomatic hepatitis C virus infection

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Abstract

A patient with severe type II cryoglobulinemia after ten years of asymptomatic hepatitis C virus (HCV) infection is reported. Laboratory data showed hypergammaglobulinemia with polyclonal IgG and monoclonal IgM, blood hyperviscosity, high level of cryocrit (60%), HCV viremia, and normal levels of serum transaminases. Due to cold exposure, acrocyanosis and cardiac ischemic attack occurred; he recovered after being artificially warmed. Administration of prednisolone and natural interferon-alpha for three months resulted in significant decreases in the levels of serum IgM and cryocrit.

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Iguchi, S., Toba, K., Fuse, I., Wada, Y., Maruyama, S., Takahashi, M., … Aizawa, Y. (1996). Severe cryoglobulinemia in a patient with asymptomatic hepatitis C virus infection. Internal Medicine, 35(9), 712–716. https://doi.org/10.2169/internalmedicine.35.712

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