Potent antiulcerogenic activity of methanol extract of Cissus quadrangularis by antioxidative mechanism

Abstract

Oxidative stress is considered to be one of the important etiological factors in various diseases including gastric ulcers. The mechanism of aspirin induced gastric lesion is mediated through lipid peroxidation. The effects of Cissus quadrangularis extract on aspirin-induced ulceration in rats with respect to its antioxidant status, lipid peroxidation, quantity of mucus and alkaline phosphatase and myeloperoxidase (MPO) activities was estimated. Cissus quadrangularis facilitated the healing of experimental gastric ulcer by increased mucus content, antioxidant defense enzyme activity and decreased MPO activity and lipid peroxides levels in the gastric mucosa. These results indicate that Cissus quadrangularis extract protects against aspirin-induced gastric mucosal lesions in rats possibly through its antioxidative action.