A comparative study of oral labetalol versus oral nifedipine in hypertensive disorders of pregnancy

Abstract

Introduction: In developed countries, 16 percent of maternal deaths were attributed to hypertensive disorders. Of hypertensive disorders, the preeclampsia syndrome is the most dangerous. Material and Methods: The Present study was conducted in Department of Obstetrics & Gynecology M.Y.H, Indore from Sept 2015 to Sept 2017.A total number of 150 patients were randomly allocated into Group A Labetalol and Group B Nifedipine, Then the effects were compared. Results: In the current study, the control of B.P. was better with nifedipine than with labetalol. Preterm labor was less with nifedipine which may be due to tocolytic effect of nifedipine but overall perinatal outcome was good in both the groups. Nifedipine gave better results in cases of hypertensive emergency. Both drugs had minimal side effects and drug compliance was better. Conclusion: Nifedipine is as safe and effective as labetalol for the management of hypertensive disorders as well as in hypertensive emergency during pregnancy.