S92 Efficacy Of Once-daily Tiotropium Respimat(R) 5  g From Five Phase Iii Trials In Adults With Symptomatic Asthma

  • Price D
  • Bateman E
  • Paggiaro P
  • et al.
N/ACitations
Citations of this article
7Readers
Mendeley users who have this article in their library.

Abstract

Background Recent clinical trials have indicated that the long-acting antimuscarinic agent tiotropium, a once-daily long-acting bronchodilator, may provide benefit to patients with symptomatic asthma. We investigated primary efficacy data (lung function, risk of severe exacerbation and seven-question Asthma Control Questionnaire [ACQ-7] response) from five Phase III, randomised, double-blind, parallel-group trials that evaluated the efficacy and safety of once-daily tiotropium add-on versus placebo add-on (all tiotropium doses delivered via the Respimat SoftMist inhaler) in adults with symptomatic asthma on inhaled corticosteroid (ICS) + long-acting beta2-agonist (LABA) maintenance therapy. Methods Two 48-week trials of tiotropium Respimat 5 mug (PrimoTinA-asthma: NCT00776984, NCT00772538) in patients on high-dose ICS (>800 mug budesonide or equivalent) + LABA; two 24-week trials of tiotropium Respimat 5 mug and 2.5 mug (MezzoTinA-asthma: NCT01172808, NCT01172821) in patients on moderate-dose ICS (400-800 mug budesonide or equivalent); one 12-week trial of tiotropium Respimat 5 mug and 2.5 mug (GraziaTinA-asthma: NCT01316380) in patients on low-dose ICS (200-400 mug budesonide or equivalent). Results 3476 patients were treated, of whom 1128 received tiotropium Respimat 5 mug. Once-daily tiotropium Respimat 5 mug significantly improved lung function (Table) in patients with not fully controlled asthma receiving low- to high-dose ICS. In addition, tiotropium Respimat 5 mug reduced the risk of severe exacerbations versus placebo (co-primary end point) in patients on high-dose ICS + LABA (hazard ratio 0.79; p = 0.0343), and there was an increase in ACQ-7 responder rate (co-primary end point) with the5 mug dose (odds ratio 1.32; p = 0.0308) compared with placebo in patients on moderate-dose ICS. Conclusion Once-daily tiotropium Respimat significantly improves lung function in adult patients with symptomatic asthma receiving a range of doses of ICS, including even high-dose ICS + LABA, suggesting a potential role for this treatment as add-on to ICS in adults with symptomatic asthma. (Table Presented).

Cite

CITATION STYLE

APA

Price, D., Bateman, E., Paggiaro, P., Kaplan, A., Engel, M., Schmidt, H., … Kerstjens, H. (2014). S92 Efficacy Of Once-daily Tiotropium Respimat(R) 5  g From Five Phase Iii Trials In Adults With Symptomatic Asthma. Thorax, 69(Suppl 2), A50–A50. https://doi.org/10.1136/thoraxjnl-2014-206260.98

Register to see more suggestions

Mendeley helps you to discover research relevant for your work.

Already have an account?

Save time finding and organizing research with Mendeley

Sign up for free