Novel Cytocidal Compounds, Oxopropalines from Streptomyces Sp. G324 Producing Lavendamycin II. Physico-Chemical Properties and Structure Elucidations

Abstract

Novel cytocidal compounds designated oxopropalines A, B, D, E and G were isolated from the fermentation of an actinomycete namedStreptomyces sp. G324, a strain that also produced an antitumor antibiotic, lavendamycin. All these compounds possessed a β-carboline chromophore. The structures of the oxopropalines were elucidated by several NMRspectral analyses and other spectroscopic experiments. © 1993, JAPAN ANTIBIOTICS RESEARCH ASSOCIATION. All rights reserved.