Inflammation: Basic Principles and Clinical Correlates

Abstract

2nd ed. Inflammation: historical perspective -- Immunoglobulins -- Complement: chemistry and pathways -- Complement: biologically active products -- Complement: molecular genetics -- Contact activation system of plasma: biochemistry and pathophysiology -- Prostaglandins and inflammation -- Leukotrienes: biosynthesis, release, and actions -- Platelet-activating factor: a fluid-phase and cell-associated mediator of inflammation -- Role of neuropeptides in inflammation -- Histamine and serotonin -- Role of interleukin-1 and tumor necrosis factor in systemic responses to infection and inflammation -- Interleukins -- Interleukin-8 and related chemotactic cytokines -- Interferon and inflammation -- Myeloid growth factors -- Developmental biology of neutrophils and eosinophils -- Development and distribution of mononuclear phagocytes -- Cell biology of phagocyte migration from the bone marrow, out of the bloodstream, and across organ epithelia -- Role of integrins in inflammation -- Selectins: carbohydrate-binding adhesion molecules of the immune system. (cont) Chemoattractant stimulus-response coupling -- Ion channels and carriers in leukocytes: distribution and functional role -- Mechanical responses of white blood cells -- Receptors for complement and the biology of phagocytosis -- Structure, signalling, and function of Fc[gamma]R -- Degranulation and secretion by phagocytic cells -- Oxygen metabolites from phagocytes -- Respiratory burst oxidase -- Oxygen-independent antimicrobial systems of phagocytes -- Macrophages as destructive cells in host defense -- Eosinophils -- High-affinity receptor for immunoglobulin E: structure, function, and role in allergy -- Mast cells and basophils -- Platelets -- Fibroblasts and matrix proteins -- Development and function of lymphocytes -- Cytotoxic activities of lymphocytes -- Wound repair -- Angiogenesis and inflammation -- Stress response and the immune system -- Disorders of phagocytic cells -- Urticaria and angioedema -- Asthma -- Pemphigus and pemphigoid: autoantibody-mediated dermatoses -- Vasculitis: pathogenic mechanisms of vessel damage. (cont) Histoplasmosis: a granulomatous inflammatory response -- Rheumatoid arthritis: a disease of disordered immunity -- Gout: crystal-induced inflammation -- Inflammatory lung disease: molecular determinants of emphysema, bronchitis, and fibrosis -- Adult respiratory distress syndrome -- Phagocyte responses to viral infection -- Asbestos exposure as a model of inflammation inducing interstitial pulmonary fibrosis -- Atherogenesis -- Adrenal corticosteroids -- Gold, penicillamine, antimalarials, and sulfasalazine -- Immunoregulatory agents -- Agents that interfere with arachidonic acid metabolism. (cont) Chemoattractant stimulus-response coupling -- Ion channels and carriers in leukocytes: distribution and functional role -- Mechanical responses of white blood cells -- Receptors for complement and the biology of phagocytosis -- Structure, signalling, and function of FcγR -- Degranulation and secretion by phagocytic cells -- Oxygen metabolites from phagocytes -- Respiratory burst oxidase -- Oxygen-independent antimicrobial systems of phagocytes -- Macrophages as destructive cells in host defense -- Eosinophils -- High-affinity receptor for immunoglobulin E: structure, function, and role in allergy -- Mast cells and basophils -- Platelets -- Fibroblasts and matrix proteins -- Development and function of lymphocytes -- Cytotoxic activities of lymphocytes -- Wound repair -- Angiogenesis and inflammation -- Stress response and the immune system -- Disorders of phagocytic cells -- Urticaria and angioedema -- Asthma -- Pemphigus and pemphigoid: autoantibody-mediated dermatoses -- Vasculitis: pathogenic mechanisms of vessel damage.