Unraveling cell death pathways during malaria infection: What do we know so far?

20Citations
Citations of this article
72Readers
Mendeley users who have this article in their library.

Abstract

Malaria is a parasitic disease (caused by different Plasmodium species) that affects millions of people worldwide. The lack of effective malaria drugs and a vaccine contributes to this disease, continuing to cause major public health and socioeconomic problems, especially in low-income countries. Cell death is implicated in malaria immune responses by eliminating infected cells, but it can also provoke an intense inflammatory response and lead to severe malaria outcomes. The study of the pathophysiological role of cell death in malaria in mammalians is key to understanding the parasite–host interactions and design prophylactic and therapeutic strategies for malaria. In this work, we review malaria-triggered cell death pathways (apoptosis, autophagy, necrosis, pyroptosis, NETosis, and ferroptosis) and we discuss their potential role in the development of new approaches for human malaria therapies.

Cite

CITATION STYLE

APA

Sena-Dos-santos, C., Braga-Da-silva, C., Marques, D., Dos Santos Pinheiro, J. A., Ribeiro-Dos-santos, Â., & Cavalcante, G. C. (2021, February 1). Unraveling cell death pathways during malaria infection: What do we know so far? Cells. MDPI. https://doi.org/10.3390/cells10020479

Register to see more suggestions

Mendeley helps you to discover research relevant for your work.

Already have an account?

Save time finding and organizing research with Mendeley

Sign up for free