Matrix Factorization for Automatic Chemical Mapping from Electron Microscopic Spectral Imaging Datasets

Abstract

As the field of autoimmune neurology develops, the role of the neurologist in the management of patients with systemic autoimmune disease is increasing. This chapter briefly reviews the neurologic manifestations, diagnostic approach, and treatment of neurosarcoidosis, IgG-4-related disease, Behçet syndrome, Sjögren syndrome, lupus, and rheumatoid arthritis. The neurologic manifestations of these conditions include parenchymal brain and brainstem disease, myelopathy, radiculopathy, myopathy, and all forms of peripheral neuropathy. Recognizing when a neurologic concern is related to immune-mediated or alternative mechanisms is a critical role for the neurologist as treatment decisions may be based on this assessment. Familiarity with the neurologic manifestations of systemic rheumatologic disease is therefore critical. The approach to treatment depends on the underlying mechanisms of disease and decisions should be made in consultation with other experts assisting in the clinical care of an individual patient.