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Modulation of the Promoter Activation Rate Dictates the Transcriptional Response to Graded BMP Signaling Levels in the Drosophila Embryo

Developmental Cell (2020) 54(6) 727-741.e7
DOI: 10.1016/j.devcel.2020.07.007
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Abstract

Hoppe et al. show that BMP target genes undergo bursts of transcriptional activity in the Drosophila early embryo. BMP signaling level modulates the frequency of transcriptional bursts by controlling the rate of promoter activation. This results in graded mRNA outputs for BMP target genes that mirror the BMP signaling gradient.

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Hoppe, C., Bowles, J. R., Minchington, T. G., Sutcliffe, C., Upadhyai, P., Rattray, M., & Ashe, H. L. (2020). Modulation of the Promoter Activation Rate Dictates the Transcriptional Response to Graded BMP Signaling Levels in the Drosophila Embryo. Developmental Cell, 54(6), 727-741.e7. https://doi.org/10.1016/j.devcel.2020.07.007

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