Mobilization of hematopoietic stem cells from the bone marrow niche to the blood compartment

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Abstract

The vast majority of hematopoietic stem cells (HSCs) reside in specialized niches within the bone marrow during steady state, maintaining lifelong blood cell production. A small number of HSCs normally traffic throughout the body; however, exogenous stimuli can enhance their release from the niche and entry into the peripheral circulation. This process, termed mobilization, has become the primary means to acquire a stem cell graft for hematopoietic transplant at most transplant centers. Currently, the preferred method of HSC mobilization for subsequent transplantation is treatment of the donor with granulocyte colony-stimulating factor. The mobilizing effect of granulocyte colony-stimulating factor is not completely understood, but recent studies suggest that its capacity to mobilize HSCs, at least in part, is a consequence of alterations to the hematopoietic niche. The present article reviews some of the key mechanisms mediating HSC mobilization, highlighting recent advances and controversies in the field. © 2011 BioMed Central Ltd.

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Hoggatt, J., & Pelus, L. M. (2011). Mobilization of hematopoietic stem cells from the bone marrow niche to the blood compartment. Stem Cell Research and Therapy. https://doi.org/10.1186/scrt54

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