Use of trans-sialidase inhibition assay in a population serologically negative for Trypanosoma cruzi but at a high risk of infection

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Abstract

trans-Sialidase inhibition assay (TIA) was employed in a population at high risk of Trypanosoma cruzi infection. From 20 serum samples that were negative by conventional serologic and parasitologic assays, 18 (90%) were reactive in TIA, providing further evidence of the higher sensitivity of TIA and suggesting that the actual prevalence of T. cruzi infection might be underestimated.

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Leguizamón, M. S., Russomando, G., De Arias, A. R., Samudio, M., Cabral, M., González-Cappa, S. M., … Campetella, O. (1998). Use of trans-sialidase inhibition assay in a population serologically negative for Trypanosoma cruzi but at a high risk of infection. Clinical and Diagnostic Laboratory Immunology, 5(2), 254–255. https://doi.org/10.1128/cdli.5.2.254-255.1998

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