Syntheses and activities of some bactobolin derivatives

Abstract

Some derivatives of bactobolin were prepared from bactobolin by dehydration or substitution reactions through tris(dimcthylamino)alkoxyphosphonium salt formation. A derivative with low toxicity, 6-deoxybactobolin, showed moderate activity against Gram-positive and Gram-negative bacteria including methicillin-resistant Staphylococcus aureus. © 1992, JAPAN ANTIBIOTICS RESEARCH ASSOCIATION. All rights reserved.