In vitro assessment of the cytotoxic effects of sulfo-arginine analogues and their hydrazide derivatives in 3T3 and HepG2 cells

Abstract

The cytotoxic activities of sulfo-arginine analogues sArg, NsArg, and their hydrazide derivatives, sArg- CONHNH2, sArg-CONHNC6H5, sArg-CONHN(CH2CH2Cl)2, NsArg-CONHNH2, NsArg-CONHNC6H5, NsArg- CONHN(CH2CH2Cl)2, on 3T3 and HepG2 cells were examined. The substitution in the carboxylic group of sArg increases the cell growth inhibitory effects of the compounds, especially in the case of the bis-(2- chloroethyl)hydrazide substitute. Similar correlation was observed in the case of NsArg and its analogues, but here the most pronounced effect was observed with the analogue NsArg-CONHNH2.