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Carcinoma Cells Reprogram a Wound-healing Switch to Promote Metastasis

Molecular and Cellular Oncology
DOI: 10.1080/23723556.2018.1432255
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Abstract

Wound healing is a dynamic event where barrier disruption is transient and miR-198/FSTL1 molecular switch orchestrate wound re-epithelialization. However, epithelial carcinomas maintain a prolonged wound-healing phase to promote malignant transformation. Delineating the molecular mechanism we demonstrate, how epidermal growth factor (EGF) hijacks the wound-healing switch to promote metastasis of carcinoma.

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Sundaram, G. M., & Sampath, P. (2018, November 2). Carcinoma Cells Reprogram a Wound-healing Switch to Promote Metastasis. Molecular and Cellular Oncology. Taylor and Francis Ltd. https://doi.org/10.1080/23723556.2018.1432255

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