619 Detecting cervical dysplasia with folate receptor-mediated detection staining agent

Abstract

Introduction/Background Colposcopy is an essential method in the diagnosis of precancerous lesions. In recent years, new adjunctive technologies have been emerging with an aim to increase the effectiveness of colposcopy. In our randomized pilot study, we tested the Folate Receptor‐mediated Detection staining solution (FRD) on 10 patients who visited our colposcopy outpatient office. Methodology In our randomized pilot study, ten patients were tested using FRD staining solution. In all 10 patients HPV Test, Pap Smear, and Colposcopy were also performed. These four methods were evaluated in regard to the histopathological findings of the targeted biopsy. Results The sensitivity and specificity of FRD staining solution were 100% and 50%, respectively. Conclusion The advantage of the FRD method is that the results are immediate. Another benefit of this test is that it can predict the location of cervical dysplasia both on the cervix and in the canal itself. Further study could be useful to check if overall accuracy for screening is improved when FRD is used as a co‐test with HPV testing.